MTB cell interactomes


K-core structure of the transcriptional regulatory network of Mycobacterium tuberculosis. Image obtained with software LaNetvi

As in most other fields in Biomedical research, the study of gene regulation in Mycobacterium tuberculosis has flourished in the last decade thanks to the generalization of next generation sequencing, transcriptomics and proteomic techniques. This have resulted in a particular big-bang of data that has been only partially exploited so far, specially from a systemic perspective.

Up to now, most of my work in this field has been distributed between two poles: the compilation and analysis of the transcriptional regulatory network (TRN) of  the bacterium, and the study of its protein-protein interactome: its structure and variations under assorted environmental stresses. By studying the topology and dynamics of these systems, and comparing them to those of other related organisms, I aim to understand the evolutionary trails left by a parasitic lifestyle on cellular interactomes.




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