Social status is one of the variables most strongly correlated to human disease and mortality risk. However, the difficulty of isolating its effects on human Physiology from those of other confounding variables (nutrition, habits, access to health care, etc.) imposes a severe limit to our current understanding of the entanglement between social adversity and Health. In this work, we study the effects of social status on gene expression patterns on a group of captive female Rhesus macaques whose hierarchical social structures can be controlled and manipulated so as to avoid potential confounders.
- N. Snyder-Mackler1, J. Sanz1, J.N. Kohn, J.F. Brinkworth, S. Morrow, A.O. Shaver, J.C. Grenier, R. Piqué-Regi, Z.P. Johnson, M.E. Wilson, L.B. Barreiro2 and J. Tung2 (1 co-first author; 2 co-last author); Social status alters immune regulation and response to infection in macaques. 2016, Science, 354(6315), 1041-1045. (article)
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