The highly variable and apparently inconsistent results obtained in BCG’s efficacy tests and meta-analysis have been subject of intense scientific controversy since more than five decades ago.
In that context, different mechanisms have been proposed to explain the variable efficacies observed for BCG in different studies. In this work, we focus on two of these hypothetical effects -the masking and blocking mechanisms-, quantifying their magnitudes and relative likelihood.
To do so, we re-analyze the data from the BCG-REVAC trials conducted in the Brazilian cities of Salvador and Manaus.
- Arregui, S., Sanz, J., Marinova, D., Martín, C., & Moreno, Y. PeerJ, 4, e1513. On the impact of masking and blocking hypotheses for measuring the efficacy of new tuberculosis vaccines. (2016) (article)
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